TRK-380, a Novel Selective Human β3-Adrenoceptor Agonist, Ameliorates Formalin-induced Pollakiuria in Rats and Carbachol-induced Bladder Contraction in Dogs

This study indicated that TRK-380 ameliorated pollakiuria, which was resistant to an antimuscarinic drug, and that it also suppressed the bladder contraction induced by cholinergic stimulation in dogs, whose bladder relaxation is known to be predominantly mediated by β3-ARs, as in humans. These data strengthen the therapeutic potential of β3-AR for the treatment of overactive bladder.