Ureteral Selectivity of Intravenous β-Adrenoceptor Agonists in Pig Model of Acute Ureteral Obstruction: Comparison of KUL-7211, a Selective β2/β3 Agonist, With Isoproterenol, Terbutaline, and CL-316243

The present results have demonstrated that in pigs, KUL-7211 is a potent ureteral relaxant with a relatively small hypotensive effect. A selective β2/β3-adrenoceptor agonist, such as KUL-7211, warrants additional investigation as a potentially useful drug for the promotion of stone passage in patients with urolithiasis.