Functional Role of Muscarinic Receptor Subtypes in Calcium Sensitization and Their Contribution to Rho-kinase and Protein Kinase C Pathways in Contraction of Human Detrusor Smooth Muscle

The results of the present study have demonstrated the predominant role of M3 receptor subtype in Ca2+ sensitization and the relative contribution to ROK and PKC pathways. Our study also shows that the ROK pathway is dominant compared with the PKC pathway after M2 receptor activation, which in turn is inferior, but not negligible, in producing Ca2+ sensitization.