Effect of Silencing VDR Gene in Kidney on Renal Epithelial Calcium Transporter Proteins and Urinary Calcium Excretion in Genetic Hypercalciuric Stone-forming Rats

Our findings suggest that VDR knockdown in the kidney can upregulate the expression of transient receptor potential vanilloid receptor subtype 5 in GHS rats. However, VDR depletion results in an increase in urine calcium excretion. The role of VDR in the hypercalciuric formation needs to be elucidated further.