Oxybutynin and Propiverine Suppress Adenosine Triphosphate-induced Bladder Overactivity Other Than Through Antimuscarinic Mechanisms

Bladder overactivity induced by intravesical instillation of ATP with protamine pretreatment was suppressed by oxybutynin, propiverine, and PPADS, and not by atropine, 4-DAMP, and methoctramine. Oxybutynin and propiverine suppress ATP-induced bladder overactivity other than through antimuscarinic mechanisms.