کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3906712 1250444 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Removal of more lymph nodes may provide better outcome, as well as more accurate pathologic findings, in patients with bladder cancer—analysis of role of pelvic lymph node dissection
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Removal of more lymph nodes may provide better outcome, as well as more accurate pathologic findings, in patients with bladder cancer—analysis of role of pelvic lymph node dissection
چکیده انگلیسی

ObjectivesTo examine the role of pelvic lymph node dissection (PLND) in patients who underwent radical cystectomy for bladder cancer. The diagnostic and therapeutic role of PLND is still controversial in bladder cancer. The extent of PLND and the necessary number of lymph nodes to remove have not been defined.MethodsThis retrospective review included 146 patients with refractory superficial and muscle-invasive disease treated with radical cystectomy, regional PLND (internal iliac, external iliac, and obturator nodes) and urinary diversion from January 1990 to December 2002.ResultsLymph node metastases were detected in 25 patients (17.1%). The average number of nodes removed in the node-positive and node-negative patients was 13.9 and 14.2, respectively. Although no difference was found in disease-specific survival in the node-negative patients when stratified by the number of nodes removed (13 or more versus less than 13), a significant survival advantage was found in the node-positive patients with 13 or more nodes removed versus less than 13 nodes removed. The patients with four or more positive nodes had a worse outcome than those with less than four positive nodes. However, even if the patients had less than four positive nodes, the survival of patients with less than 13 nodes removed was as poor as that of the patients with four or more positive nodes.ConclusionsIn this series, the removal of 13 or more pelvic lymph nodes was essential for more accurate pathologic examination to predict patient outcome and contributed to an increased chance of survival.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Urology - Volume 68, Issue 3, September 2006, Pages 543–548
نویسندگان
, , , , , , , , , ,