کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3907372 1251044 2014 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thromboembolism in pregnancy: Challenges and controversies in the prevention of pregnancy-associated venous thromboembolism and management of anticoagulation in women with mechanical prosthetic heart valves
ترجمه فارسی عنوان
ترومبوآمبولی در دوران بارداری: چالشها و اختلافات در پیشگیری از ترومبوآمبولی وریدی و مدیریت آنتی باکتریال در زنان با دریچه های قلب پروتز مکانیکی
کلمات کلیدی
ترومبوآمبولی وریدی، بارداری، دریچه های قلب پروتز مکانیکی، ترومبوفیلیکسیس، وارفارین، هپارین کم مولکولی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

Thromboembolism in pregnancy is an important clinical issue. Despite identification of maternal and pregnancy-specific risk factors for development of pregnancy-associated venous thromboembolism, limited data are available to inform on optimal approaches for prevention. The relatively low overall prevalence of pregnancy-associated venous thromboembolism has prompted debate about the validity of recommendations, which are mainly based on expert opinion, and have resulted in an increased use of pharmacological thromboprophylaxis in pregnancy and postpartum. A pragmatic approach is required in the absence of more robust data. Anticoagulation management of pregnant women with mechanical prosthetic heart valves is particularly challenging. Continuation of therapeutic anticoagulation during pregnancy is essential to prevent valve thrombosis. Warfarin, the most effective anticoagulant, is associated with adverse fetal outcomes, including embryopathy and stillbirth. Fetal outcome is improved with therapeutic-dose low-molecular-weight heparin, but there may be more thromboembolic complications. More intensive anticoagulation, targeting higher trough anti-Xa levels, may reduce the risk of valve thrombosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Obstetrics & Gynaecology - Volume 28, Issue 4, May 2014, Pages 519–536
نویسندگان
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