کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3907865 1251086 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bone health and osteoporosis in postmenopausal women
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Bone health and osteoporosis in postmenopausal women
چکیده انگلیسی

Osteoporosis-related fractures affect one-third of postmenopausal women, resulting in significant morbidity, mortality and cost. Bone strength is compromised if bone remodelling favours resorption by osteoclasts over bone formation by osteoblasts. Understanding the regulation of remodelling holds the key to the management of osteoporosis. Postmenopausal women should be encouraged to embrace lifestyle changes that benefit bone health. Pharmacological intervention should be reserved for patients at risk of fracture, determined with the 10-year probability of fracture using an integrated model of risk factors (FRAX). Randomized controlled trials have shown that oestrogen/progestin hormone therapy, selective oestrogen receptor modulators, bisphosphonates, teriparatide and strontium ranelate are effective in the prevention of osteoporotic fractures. No head-to-head comparative data are available. Compliance with therapy is poor and treatment monitoring relies on surrogate markers. Every effort must be made to prevent osteoporotic fractures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Obstetrics & Gynaecology - Volume 23, Issue 1, February 2009, Pages 73–85
نویسندگان
,