کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3908794 | 1251194 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The use of one step nucleic-acid amplification (OSNA) in clinical practice: A single-centre study The use of one step nucleic-acid amplification (OSNA) in clinical practice: A single-centre study](/preview/png/3908794.png)
BackgroundThe development of intraoperative sentinel node biopsy (SLNB) analysis methods, such as One-Step Nucleic Acid Amplification (OSNA), has made single-stage procedures possible.AimsWe investigated the incidence of OSNA-detected lymph node positivity, comparing it to conventional histopathology, the incidence of non-SLNB node disease for the OSNA positive patients, and the breast re-operation rate, to assess the benefit from single-stage procedures.MethodsThis was a single-centre series of 573 consecutive patients undergoing SLNB (173 histopathology and 400 OSNA).ResultsOSNA-detected SLNB macrometastasis was similar to routine histopathology, with more micrometastasis detected (p < 0.001). Non-SLNB involvement in the OSNA group was similar to documented histopathological series. 27.6% of OSNA patients avoided further surgery because of OSNA. The median time for OSNA results was 42 min.ConclusionsOSNA is an effective method for detecting SLNB-metastasis. It is easily used in clinical practice, providing reliable results and negating the need for a second axillary operation.
Journal: The Breast - Volume 22, Issue 2, April 2013, Pages 162–167