کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3909602 1251220 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures
چکیده انگلیسی

AimsAchieving negative margins is essential in conservative treatment for breast cancer. The conventional method for intra-operative assessment of resection margins is gross or histological examination of frozen sections. We describe and evaluate the contribution of an original intra-operative touch preparation cytology (IOTPC) technique (400 procedures) performed on 396 patients.Materials and methodsIOTPC consists of touching glass slides to the surfaces of interest after gently pressing the spatially localized specimen taken according to predetermined conditions. The result is conveyed to the surgeon immediately and compared with the conventional histological findings after embedding in paraffin.ResultsThe average response time is 10 min, which renders the technique compatible with standard operating room procedures and its cost is reasonable. The method has a sensitivity of 88.6%, specificity of 92.2%, positive predictive value of 73.6%, negative predictive value of 97%, and correlation with paraffin section histology of 91.5%. Only 5 true false negatives were found in this series and the technique prevented 11.75% of secondary re-excision procedures for positive margins.ConclusionIOTPC is a reliable extemporaneous method for assessing surgical margins in conservative treatment for breast cancer and a useful tool for surgeons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 18, Issue 4, August 2009, Pages 248–253
نویسندگان
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