کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3909724 1251227 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exemestane after non-steroidal aromatase inhibitors for post-menopausal women with advanced breast cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Exemestane after non-steroidal aromatase inhibitors for post-menopausal women with advanced breast cancer
چکیده انگلیسی

SummaryA retrospective analysis was performed on 31 consecutive locally advanced or metastatic breast cancer patients who commenced exemestane 25 mg/d orally following previous treatment with Tamoxifen and a non-steroidal third-generation aromatase inhibitor (AI). Patients were seen 3 monthly until clinical or radiological disease progression.Median age was 64 years (range 34–90 yrs). The average number of recurrences before starting exemestane was three (range 1–6). There were two complete responses (CR), four partial responses (PR), 12 with stable disease (SD) and 12 with progressive disease (PD). Objective response rate (CR+PR) was 19.4% and overall clinical benefit (CR+PR+SD ⩾24 weeks) was 54.8%. The median durations of objective response and overall clinical benefit were 18 and 14 months, respectively.This data support the anti-tumour activity of exemestane 25 mg daily in patients with locally advanced and/or metastatic breast cancer who have been previously exposed to non-steroidal AIs and Tamoxifen.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 16, Issue 4, August 2007, Pages 436–439
نویسندگان
, , , ,