کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3909964 1251237 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pilot study of the impact of letrozole vs. placebo on breast density in women completing 5 years of tamoxifen
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Pilot study of the impact of letrozole vs. placebo on breast density in women completing 5 years of tamoxifen
چکیده انگلیسی

SummaryBreast density, a strong risk factor for breast cancer, is reduced by the anti-estrogen, tamoxifen (TAM). We examined whether aromatase inhibitor (AI) therapy results in further reductions in breast density among women completing 5 years of TAM. Among a sample of women with early-onset breast cancer who were randomized to letrozole (LET)(n=56) or placebo (PLAC)(n=48) after 5 years of TAM, we examine the change in percent density at 9–15 months as well as a per-year change in PD by treatment group. There was no difference in the adjusted mean change (−1.0%, LET; −0.3%, PLAC (P=0.58)) or the percentage change (−2.7%, LET; −3.0%, PLAC (P=0.96)) in PD between treatment groups at 9–15 months. Results were similar for longitudinal change (−0.68% per year, LET; −0.12% per year, PLAC (P=0.23)). Breast density does not appear to be a clinically relevant biomarker in women who already have low PD following 5 years of TAM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 16, Issue 2, April 2007, Pages 204–210
نویسندگان
, , , , , , ,