کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3913416 | 1251437 | 2013 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A modified SILCS contraceptive diaphragm for long-term controlled release of the HIV microbicide dapivirine A modified SILCS contraceptive diaphragm for long-term controlled release of the HIV microbicide dapivirine](/preview/png/3913416.png)
BackgroundThere is considerable interest in developing new multipurpose prevention technologies to address women's reproductive health needs. This study describes an innovative barrier contraceptive device — based on the SILCS diaphragm — that also provides long-term controlled release of the lead candidate anti-HIV microbicide dapivirine.Study DesignDiaphragm devices comprising various dapivirine-loaded polymer spring cores overmolded with a nonmedicated silicone elastomer sheath were fabricated by injection molding processes. In vitro release testing, thermal analysis and mechanical characterization were performed on the devices.ResultsA diaphragm device containing a polyoxymethylene spring core loaded with 10% w/w dapivirine provided continuous and controlled release of dapivirine over a 6-month period, with a mean in vitro daily release rate of 174 mcg/day. The mechanical properties of the new diaphragm were closely matched to the SILCS diaphragm.ConclusionsThe study demonstrates proof of concept for a dapivirine-releasing diaphragm with daily release quantities potentially capable of preventing HIV transmission. In discontinuous clinical use, release of dapivirine may be readily extended over 1 or more years.
Journal: Contraception - Volume 88, Issue 1, July 2013, Pages 58–66