کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3915951 1251527 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Release behavior of copper ion in a novel contraceptive composite
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Release behavior of copper ion in a novel contraceptive composite
چکیده انگلیسی

PurposeThe universally used contraceptive method, the Cu-IUD, an effective contraceptive, is being increasingly used worldwide for family planning. To avoid abnormal bleeding, pain, partial and complete expulsion associated with the burst release of copper during the first few days, a novel cross-linked composite based on poly vinyl alcohol (PVA) that contains copper ions, but not metallic copper, was synthesized.Material and MethodsPVA, well known for its good processability, high strength, long-term temperature and pH stability and biocompatibility, was used as the matrix material. The corrosion products and the release rate of copper ions after soaking in simulated body fluid (SBF) for different time spans were studied by environmental scanning electron microscopy, X-ray energy dispersive spectroscopy, X-ray diffraction and atomic absorption spectrophotometer.ResultsNo significant change on time dependence for the release rate of copper ions in the composite compared with that of metallic copper was found. Moreover, no other new elements, such as P, Cl and Ca, appeared on the surface of the composite and no Cu2O formed after immersing in SBF for 90 days.ConclusionBurst release of copper ions can be avoided by loading copper ions in this polymer material. Release channels would not be obstructed by the deposition of corrosion products and nearly all of the copper loaded in the composites could be an effective contraceptive.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contraception - Volume 76, Issue 3, September 2007, Pages 233–237
نویسندگان
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