کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3916020 1251530 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of a continuous regimen of levonorgestrel/ethinyl estradiol: phase 3 study results
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Evaluation of a continuous regimen of levonorgestrel/ethinyl estradiol: phase 3 study results
چکیده انگلیسی

ObjectiveThis study was conducted to evaluate the safety and efficacy of a continuous daily regimen of levonorgestrel (LNG) 90 μg/ethinyl estradiol (EE) 20 μg (continuous LNG/EE).MethodsHealthy women aged 18–49 years with regular menstrual cycles for 3 months enrolled in this single-treatment open-label study and took one pill of LNG 90 μg/EE 20 μg daily for 12 months.ResultsFor the 2134 subjects enrolled, the Pearl Index method failure was 1.26, and user failure was 0.34. While on Pill Pack 13, 58.7% of subjects reported amenorrhea and 79.0% reported absence of bleeding. Overall, the number of bleeding and spotting days per pill pack declined progressively. Adverse events and discontinuations were comparable to those reported for cyclic oral contraceptive (OC) regimens, except for higher rates in those related to uterine bleeding.ConclusionsContinuous LNG/EE demonstrated a good safety profile and efficacy similar to cyclic OCs. The regimen continuously inhibited menses, increased the incidence of amenorrhea over time and, except for a subset of women, decreased the number of bleeding and spotting days.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contraception - Volume 74, Issue 6, December 2006, Pages 439–445
نویسندگان
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