کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3916023 | 1251530 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mifepristone and misoprostol for the treatment of early pregnancy failure: a pilot clinical trial Mifepristone and misoprostol for the treatment of early pregnancy failure: a pilot clinical trial](/preview/png/3916023.png)
BackgroundIn an attempt to improve efficacy for women who desire medical management of early pregnancy failure (EPF), we studied the efficacy and acceptability of mifepristone 200 mg, orally (po), followed 24 h later by misoprostol 800 μg, vaginally (pv), for the treatment of EPF.MethodsWe enrolled 30 women with EPF in this pilot clinical trial. All women used misoprostol 800 μg, pv, 24 h after ingesting 200 mg mifepristone. Follow-up evaluations with transvaginal ultrasonography occurred at 24 h and 1 week after treatment. Participants were offered a repeat dose of misoprostol if the pregnancy had not been expelled at the first follow-up.ResultsThe expulsion rate with one dose of misoprostol was 90% (95% CI=79–100%). The overall success rate of the treatment was 93% (95% CI=84–100%).ConclusionThis regimen of mifepristone followed by vaginal misoprostol appears to be an efficacious and acceptable treatment for EPF and may have improved results over a single dose of misoprostol alone.
Journal: Contraception - Volume 74, Issue 6, December 2006, Pages 458–462