کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3917713 1252145 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The ELGAN study of the brain and related disorders in extremely low gestational age newborns
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The ELGAN study of the brain and related disorders in extremely low gestational age newborns
چکیده انگلیسی

BackgroundExtremely low gestational age newborns (ELGANs) are at increased risk for structural and functional brain abnormalities.AimTo identify factors that contribute to brain damage in ELGANs.Study designMulti-center cohort study.SubjectsWe enrolled 1506 ELGANs born before 28 weeks gestation at 14 sites; 1201 (80%) survived to 2 years corrected age. Information about exposures and characteristics was collected by maternal interview, from chart review, microbiologic and histological examination of placentas, and measurement of proteins in umbilical cord and early postnatal blood spots.Outcome measuresIndicators of white matter damage, i.e. ventriculomegaly and echolucent lesions, on protocol cranial ultrasound scans; head circumference and developmental outcomes at 24 months adjusted age, i.e., cerebral palsy, mental and motor scales of the Bayley Scales of Infant Development, and a screen for autism spectrum disorders.ResultsELGAN Study publications thus far provide evidence that the following are associated with ultrasongraphically detected white matter damage, cerebral palsy, or both: preterm delivery attributed to preterm labor, prelabor premature rupture of membranes, or cervical insufficiency; recovery of microorganisms in the placenta parenchyma, including species categorized as human skin microflora; histological evidence of placental inflammation; lower gestational age at delivery; greater neonatal illness severity; severe chronic lung disease; neonatal bacteremia; and necrotizing enterocolitis.ConclusionsIn addition to supporting a potential role for many previously identified antecedents of brain damage in ELGANs, our study is the first to provide strong evidence that brain damage in extremely preterm infants is associated with microorganisms in placenta parenchyma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Early Human Development - Volume 85, Issue 11, November 2009, Pages 719–725
نویسندگان
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