کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3919462 1599784 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A prospective randomized trial comparing the use of tolterodine or weighted vaginal cones in women with overactive bladder syndrome
ترجمه فارسی عنوان
یک مطالعه کارآزمایی بالینی تصادفی با مقایسه استفاده از تولوترودین یا مخروط های واژینال وزنی در زنان مبتلا به سندرم حاد هیپوفیز
کلمات کلیدی
مثانه بسیار فعال تولوترودین، مخروط واژینال، اثر، تمرین کف پا
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

ObjectiveTo compare the efficacy of pelvic floor muscle exercises (PFME) using weighted vaginal cones (WVC) on the symptoms, clinical findings, urodynamic findings and quality of life (QoL) in overactive bladder (OAB) patients with tolterodine.Study designThirty-nine patients with urinary frequency (≥8/day), nocturia (≥2/night), urgency and a total score of ≥8 to the overactive bladder-awareness tool (OAB-V8) were diagnosed as OAB and were randomized into two treatment groups; WVC and extended release tolterodine (tolterodine ER) 4 mg/day for 8 weeks. Results of the clinical findings, 3-day urinary diary, validated questionnaires for symptom bother and QoL (Urinary distress inventory (UDI-6), incontinence impact questionnaire (IIQ-7), OAB-V8, Wagner questionnaire) and urodynamic examination before and after treatment were compared.ResultsA reduction of frequency, nocturia and urinary incontinence was observed in WVC group (p = 0.006, p = 0.034 and p = 0.008, respectively) and in tolterodine group (p < 0.001, p = 0.002 and p = 0.035, respectively). 24-h dry pad test results were improved significantly in both groups (p = 0.003 and p = 0.001, respectively). Pelvic muscle strength was significantly improved in WVC group but not in tolterodine group (p = 0.010 and p = 0.180, respectively). UDI-6, IIQ-7, OAB-V8 scores were improved significantly in both groups. Improvements in Wagner questionnaire were observed in WVC group but not in tolterodine group (p = 0.002 and p = 0.591, respectively). First sensation of bladder filling was significantly improved after WVC treatment but not in tolterodine group (p = 0.035 and p = 0.550, respectively). After treatment, detrusor overactivity (DO) resolved in 8 patients in the WVC group (p = 0.003) and in 2 patients in the tolterodine group (p = 0.426).ConclusionsWVC treatment seems to be an efficacious therapeutic option for the improvement of overactive bladder syndrome (OABS).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 197, February 2016, Pages 91–97
نویسندگان
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