GnRH-antagonist programming versus GnRH agonist protocol: a randomized trial

ObjectiveTesting the ability to program IVF GnRH-antagonist cycles to avoid weekend oocyte retrieval.Study designPreliminary randomized clinical trial. Patients presenting an indication for IVF or IVF-ICSI were assigned into either the Treatment Group – GnRH antagonist protocol, programmed to start stimulatory agents on a Friday, with oral 2 mg estradiol valerate twice a day from the 2nd day of cycle until the first Friday to follow, or to the Control Group – long luteal GnRH agonist protocol.ResultsThe performance of 27 Treatment Group patients and 24 Control Group patients was analyzed. Cycle dynamics were not clinically or statistically different except for a significant difference in the number of follicles measuring ≥18 mm on hCG administration day. There were no differences in the number of aspirated ova, fertilization rates, embryo quality or number of embryos to be transferred. Pregnancy rate was 41.7% in the Treatment Group and 50% in the Control Group (P > 0.5). Only one patient assigned to the Treatment Group had a weekend retrieval.ConclusionsPreliminary results demonstrate no compromise related to follicular estrogen programming in a GnRH antagonist protocol and provide reassurance regarding the ability to achieve programming goals.