کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3919880 | 1599804 | 2014 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Performance of self-sampled HPV test in comparison with liquid based cytology Performance of self-sampled HPV test in comparison with liquid based cytology](/preview/png/3919880.png)
ObjectiveStrong evidences shows that HPV testing is more sensitive than cytology in detecting high-grade CIN. HPV test can be performed on samples collected by women themselves by means of self-sampling devices. This study compares the results of self-sampled HPV tests with the results of liquid based cytology (LBC).Study designSeven hundred women scheduled for cervical cytology self-collected a cervicovaginal sample for HPV testing and then underwent a clinician-collected LBC at the European Institute of Oncology. The HPV and LBC results were compared with the McNemar test.ResultsAll HSIL (N = 5) resulted hrHPV positive. LBC resulted LSIL or worse in 38 (5.4%) women (out of 700). Self-sampled HPV was positive in 96 women (13.7%). A LSIL or worse LBC result was found in 15 (2.5%) patients, out of the 604 hrHPV negative women and in 23 (24%) patients, out of the 96 hrHPV positive women. Positive cytology after a self-sampled HPV positive result had an Odds Ratio of 12.4 (95% CI: 5.8–26.6).ConclusionSelf-collected HPV testing identifies a group of women at high risk of positive LBC and high grade SIL.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 177, June 2014, Pages 72–76