کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3920855 | 1599837 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A hydrogel for adhesion prevention: characterization and efficacy study in a rabbit uterus model A hydrogel for adhesion prevention: characterization and efficacy study in a rabbit uterus model](/preview/png/3920855.png)
ObjectivePostoperative peritoneal adhesions following gynaecological surgery remain a clinically relevant problem. One approach to prevent adhesion formation is to apply physical barriers such as hydrogels.Study designA physically crosslinked polyvinyl alcohol and carboxymethylcellulose (PVA/CMC) hydrogel (A-Part) was characterized in vitro. Three different traumatization methods were evaluated in a rabbit uterine study. To determine its anti-adhesion efficacy, the hydrogel was first tested in an in vivo pilot study and then in a larger trial to compare it with icodextrin 4% solution (Adept®) and controls.ResultsRheological measurements showed an increased elasticity of the hydrogel after freezing. In vivo experiments revealed a clear reduction in incidence, extent and severity of adhesions compared to the icodextrin 4% solution and the untreated control group.ConclusionsThese results warrant further investigation of the PVA/CMC A-Part hydrogel in clinical trials focused on gynaecological procedures.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 158, Issue 1, September 2011, Pages 67–71