کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3921137 1599860 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amniotic fluid urocortin, CRF, oestriol, dehydroepiandrosterone sulfate and cortisol concentrations at mid-trimester: putative relationship with preterm delivery
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Amniotic fluid urocortin, CRF, oestriol, dehydroepiandrosterone sulfate and cortisol concentrations at mid-trimester: putative relationship with preterm delivery
چکیده انگلیسی

ObjectiveStress-related peptide and steroid hormones are involved in the pathogenesis of preterm delivery, even though their clinical usefulness as predictive markers of preterm delivery remains unclear. The present study evaluated whether mid-trimester amniotic fluid concentrations of stress-related peptides, that is corticothophin-releasing factor (CRF) and urocortin (Ucn) and feto-placental steroids (oestriol, DHEA-S and cortisol) correlated with preterm delivery.Study designIt is a retrospective case–control study. Healthy women (n = 130) undergoing amniocentesis at mid-gestation for genetic indications, of whom 15 had a preterm delivery (cases) and 115 delivered at term (controls). CRF, urocortin, cortisol, DHEA-S and oestriol concentrations were measured by specific and sensitive immunoenzymatic assays.ResultsAmniotic fluid urocortin concentrations in the cases (0.50 ± 0.07 ng/ml) (M ± SD) were significantly lower (P < 0.0001) than in the control group (0.90 ± 0.26 ng/ml), while CRF concentrations did not differ between the cases (1.52 ± 0.39 ng/ml) and control group (1.64 ± 0.68 ng/ml). Amniotic fluid cortisol (17.71 ± 3.72 ng/ml vs. 17.32 ± 3.17 ng/ml), DHEA-S (0.16 ± 0.06 ng/ml vs. 0.17 ± 0.09 ng/ml) and oestriol (4.68 ± 1.95 ng/ml vs. 4.79 ± 1.84 ng/ml) concentrations were similar in the two groups.ConclusionsThe low amniotic fluid concentrations of urocortin at mid-trimester may be a signal of predisposition to preterm delivery, while the unchanged CRF and steroid hormones concentrations in women delivering preterm suggest that this mechanisms are not yet activated at mid-trimester.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 146, Issue 2, October 2009, Pages 169–173
نویسندگان
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