کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3921391 1599893 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: A pilot study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: A pilot study
چکیده انگلیسی

ObjectiveTo analyze the dermal collagen of 15 postmenopausal women who had being treated with systemic estrogen replacement before and after using topical a 0.01% estrogen treatment.MethodsFifteen patients were included in this clinical trial using the systemic estrogen therapy for at least 1 year (minimum and maximum lengths of therapy were 13 and 40 months, respectively). A facial punch was performed in the preauricular area for collecting samples before and after the 16 weeks of treatment. Blood samples were also collected for estradiol level determination. The morphometric determination of epithelial and dermal thickness as well as dermal collagen were measured using a suitable software. The paired Student's t-test was used for statistical analysis.ResultsThe epithelial and dermal thickness enhanced after the topic estrogen therapy (P < 0.01). The amount of collagen significantly increased after 16 weeks of treatment (P < 0.001). The estrogen levels did not significant increase after the topical therapy (P ≥ 0.05).ConclusionOur data suggested that topical estrogen associated to systemic estrogen therapy seems to increase the expression of skin collagen amount, which may prove to be beneficial for the postmenopausal facial skin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 130, Issue 2, February 2007, Pages 202–205
نویسندگان
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