کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3921424 1599858 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence of measles virus antigens and RNA in endometrial cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Evidence of measles virus antigens and RNA in endometrial cancer
چکیده انگلیسی

ObjectivesTo look for an association between the measles virus and endometrial carcinoma, the most frequent cancer of the female genital tract in our area.Study designThirty-six of 49 patients with endometrial carcinoma were studied to detect fingerprints of the measles virus. Immunohistochemistry with the avidin–biotin complex method and in situ hybridization were used to demonstrate the association. The clinicopathological correlations were carried out to support a relationship between the virus and the cancer if any was found.ResultsTwenty-six of the 36 cases (72%) of endometrial cancer showed the presence of measles virus antigens in the tumor cells. Sixteen of 21 cases were positive for measles virus RNA by in situ hybridization. Although type I endometrial carcinoma was more positive for viral particles than type II, type II cancer, when allied with the measles virus, was more often associated with the depth of myometrial invasion and with death from tumor.ConclusionsWe demonstrate for the first time a link between endometrial cancer and the presence of viral antigens and RNA of the measles virus, although these findings do not necessarily signify a causal relationship between the cancer and the virus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 147, Issue 2, December 2009, Pages 206–209
نویسندگان
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