کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3921613 | 1599863 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Association between a single nucleotide polymorphism in MTHFR gene and polycystic ovary syndrome Association between a single nucleotide polymorphism in MTHFR gene and polycystic ovary syndrome](/preview/png/3921613.png)
ObjectiveThe aim of the present study was to investigate whether there is an association between the C677T polymorphism in MTHFR and PCOS in a Korean population.Study designThe prevalence of MTHFR gene was compared between women with PCOS (n = 227) and normal patients (n = 115) using restriction fragment length polymorphism (RFLP) analysis. The HapAnalyzer was used to analyze the genotype of MTHFR polymorphism in PCOS and control subjects. We considered a p-value less than 0.05 as statistically significant.ResultsThe frequency of C/C, C/T, and T/T genotype showed similar proportion between PCOS and control subjects. In addition, the frequencies of co-dominant (p-value = 0.8334, odds ratio (OR) = 1.04), dominant (p-value = 0.8749, OR = 0.96) and recessive alleles (p-value = 0.5574, OR = 1.22) did not show any association between PCOS and control subjects.ConclusionOur data demonstrate that the C677T polymorphism of MTHFR gene is not associated with PCOS in a Korean population, suggesting that the C677T polymorphism in MTHFR may have different influences in various ethnic groups and diseases.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 145, Issue 1, July 2009, Pages 85–88