کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3921678 | 1599885 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: TNFA-308G>A polymorphism influences the TNF-α response to altered vaginal flora TNFA-308G>A polymorphism influences the TNF-α response to altered vaginal flora](/preview/png/3921678.png)
ObjectiveTo investigate the association between a tumor necrosis factor-α (TNF-α) gene polymorphism, vaginal TNF-α level, and microbial flora in pregnant women.MethodsVaginal samples from 203 women at 18–22 weeks’ gestation were analyzed for microflora. TNFA-308G>A polymorphism was analyzed by polymerase chain reaction and restriction endonuclease analysis and TNF-α concentration was determined by ELISA. Outcome data were subsequently obtained.ResultsThe vaginal TNF-α concentration was elevated in TNFA-308A carriers only in the presence of abnormal vaginal flora. A median TNF-α level of 10.94 pg/ml in TNFA-308A carriers with bacterial vaginosis (BV) was significantly higher than that of 1.77 pg/ml in TNFA-308A carriers without BV (P = .02), and 1.72 pg/ml in TNF-308G homozygotes with BV (P = .01).ConclusionThe TNFA-308G>A polymorphism influences the local TNF-α response to altered vaginal microflora. This suggests that the nature of the host response to microbial invasion in the lower female genital is genetically determined.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 134, Issue 2, October 2007, Pages 188–191