کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3921685 1599885 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Presurgical short term treatment of uterine fibroids with different doses of cetrorelix acetate: A double-blind, placebo-controlled multicenter study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Presurgical short term treatment of uterine fibroids with different doses of cetrorelix acetate: A double-blind, placebo-controlled multicenter study
چکیده انگلیسی

ObjectiveTo assess the efficacy and safety of different dosing schedules of cetrorelix acetate as a short term treatment for 4 weeks prior to surgery in patients with uterine fibroids.Study designRandomized, double-blind, placebo-controlled study. Patients were 109 premenopausal women, with at least one uterine fibroid, more than 4 cm in diameter. Groups 1–3 received placebo, 5 and 10 mg of cetrorelix on days 1, 8, 15 and 22, respectively group 4 received 10 mg of cetrorelix on days 1 and 15. MRI scan was performed at screening and on day 29. The main outcome measure was the reduction of uterine volume on day 29 and response, defined as >30% size reduction.ResultsMean (±S.D.) reduction of uterine volume on day 29 (MRI scan) was 5.1 ± 32.1% with placebo, 15.6 ± 20.2% with 4 × 5 mg, 15.4 ± 34.6% with 4 × 10 mg and 0.6 ± 30.6% with 2 × 10 mg cetrorelix. Significant response versus placebo (p < 0.05) occurred in the 4 × 10 mg group (42.3% versus 11.1%)ConclusionsBest objective response after 4 weeks of treatment was achieved after therapy with 4 × 10 mg of cetrorelix acetate. Short term presurgical treatment with the LHRH-antagonist cetrorelix is a flexible treatment protocol without any major side effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 134, Issue 2, October 2007, Pages 225–232
نویسندگان
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