کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3921722 | 1599897 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prediction of preterm delivery using changes in serum relaxin in low risk pregnancies Prediction of preterm delivery using changes in serum relaxin in low risk pregnancies](/preview/png/3921722.png)
ObjectiveTo examine serum relaxin as a predictor of spontaneous preterm delivery.Study designA prospective study of 2846 women with singleton pregnancies, from which a matched case–control study (84 cases of spontaneous preterm delivery before 37 weeks gestation and 175 controls) and a cohort (84 preterm and 399 term deliveries) were extracted.ResultsIn the women with a subsequent preterm delivery the relaxin level decreased by 0.9% per week as compared to 1.9% per week (t-test, p = 0.004) in the women with term deliveries. From the cohort the course of S-relaxin during pregnancy in both preterm and term deliveries were fitted and graphed. S-relaxin level was raised in women who were hormonally stimulated to obtain pregnancy (p = 0.0001), and lower in women with pre-pregnancy overweight (BMI ≥ 25, p = 0.01) as well as in women, who had previously been pregnant (p = 0.008). A longitudinal adjusted model for the prediction of preterm delivery based on the change in S-relaxin was established.ConclusionsS-relaxin levels decrease less rapidly in women who subsequently deliver preterm; this results in elevated S-relaxin levels in the second and the third trimesters.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 128, Issues 1–2, September–October 2006, Pages 113–118