کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3921933 | 1599879 | 2008 | 5 صفحه PDF | دانلود رایگان |
ObjectiveTo evaluate whether C-reactive protein (CRP) serum levels can be used as prognostic parameter in patients with vulvar cancer.Study designCRP serum levels were measured at the time of first diagnosis of squamous cell vulvar cancer. Sixty-seven patients were enrolled; results were correlated to clinical data.ResultsMean CRP serum levels in patients with vulvar cancer were 0.8 (0.80) mg/dL. CRP serum levels were significantly associated with lymph node involvement (p = 0.003), but not with tumor stage (p = 0.03), histological grade (p = 0.86) and patients’ age (p = 0.64). Univariate analysis showed lymph node involvement, tumor stage and histological grade, but not CRP serum levels and patients’ age to be associated with overall survival. A multivariable analysis determined only lymph node involvement as independent prognostic parameter for disease-free interval and overall survival.ConclusionCRP serum levels are closely associated with lymph node status but cannot be used as prognostic parameter in patients with vulvar cancer.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 137, Issue 2, April 2008, Pages 217–221