کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3922279 1599890 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Management of multicentric lesions of the lower genital tract
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Management of multicentric lesions of the lower genital tract
چکیده انگلیسی

ObjectivesTo report management and outcome of multicentric lesions of the lower genital tract. To define risk factors of recurrence.Study designRetrospective review of multicentric dysplasias treated in our colposcopic clinic between 1996 and 2003. Multicentric dysplasias included CIN with VAIN and/or VIN. After primary treatment, follow-up was colposcopic, cytologic and virologic.ResultsForty-four patients presented multicentric lesions out of 998 patients referred for CIN (4.4%). The average age was 36.8 years. Immunologic disorders were present in 20.4%. Ninety-one percent had cervicovaginal or cervicovulvar lesions, only 9% had three sites of genital dysplasia. 53.3% of lesions were concomitant. 79.5% of CIN were high grade, 62.5% of VAIN low grade and 62.5% of VIN high grade. Therapeutic modalities were as follows: conization for CIN (70.4%), CO2 laser for VAIN (33.3%) and surgery for VIN (41.7%). Forty patients were followed and had at least one post-treatment cytologic control; 55% of them had residual disease. Out of the 23 patients with at least two negative controls after treatment, 43.5% presented recurrence. Risk of recurrence was not statistically bound to such parameters as tabagism, immunologic disorder, high grade lesions, non-surgical treatment, and persistence of HPV infection after treatment.ConclusionMulticentric dysplasias are associated with high rate of residual lesion and recurrence. Management of these lesions require long term follow-up.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 132, Issue 1, May 2007, Pages 116–120
نویسندگان
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