کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3922315 | 1599899 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of adenosine 5′-triphosphate on calcium mobilization and cell proliferation in cervical cancer cells
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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چکیده انگلیسی
ObjectiveTo know the effect of adenosine 5′-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells.Study designFour different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines.ResultsExtracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-κB in all cell lines used.ConclusionThese results suggest that calcium mobilization and NF-κB dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 127, Issue 1, July 2006, Pages 110–114
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 127, Issue 1, July 2006, Pages 110–114
نویسندگان
Seok Geun Lee, Jung-Kyoung Choi, Byung Hyune Choi, Young Lim, Young-Hoon Kim, Kweon-Haeng Lee, Jong Chul Shin, Woong Shick Ahn,