کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3922332 | 1599880 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Phenytoin but not valproate directly affected in vitro trophoblast differentiation Phenytoin but not valproate directly affected in vitro trophoblast differentiation](/preview/png/3922332.png)
ObjectiveEpilepsy has been associated with poor obstetric outcomes that could be the result of the epilepsy itself or a direct effect of anti-epileptic medication on placentation. The aim of this study was to investigate any direct effect of anti-epileptic drugs on an established, in vitro bioassay of trophoblast differentiation.Study designPrimary extravillous trophoblast cells were cultured in the presence of phenytoin and sodium valproate at a range of concentrations with appropriate solvent controls. The formation of multinuclear giant cells was used as a marker of trophoblast differentiation.ResultsPhenytoin inhibited giant multinuclear cell formation in a dose-dependent manner; in contrast sodium valproate had no effect (p = 0.011).ConclusionsThis study found that two anti-epileptic medications induced different effects on an in vitro trophoblast bioassay, suggesting that further research should be aimed at elucidating which anti-epileptic medication is most suitable for pregnant women.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 137, Issue 1, March 2008, Pages 31–36