Consistency of medical abortion efficacy from 5 through 14 weeks’ gestation

ObjectiveTo assess the efficacy of medical abortion performed according to a single protocol from 5 through 14 weeks.Study designRetrospective observational study of medical abortions through 14 weeks performed from January 2000 through August 2001. The protocol combined 400 mg of mifepristone orally, followed 48 h later by 800 μg of misoprostol, administered vaginally, and repeated after 4 h if the patient did not begin to abort. Outcome measures were the abortion rate, the rates of immediate manual uterine revision and of secondary vacuum aspiration, the time to expulsion, the misoprostol dose, and analgesic use.ResultsThe study included 512 medical abortions. The abortion rate was 98.4% and the secondary vacuum aspiration rate 8.2%. The uterine exploration rate was 1.4%, but these occurred only at gestations above 13 weeks. The mean time to expulsion was 4.4 ± 1.9 h (1–28), and the mean misoprostol dose 860 ± 180 μg (0–2000). None of the characteristics studied differed significantly as a function of gestation. 1.6% of patients had complications.ConclusionMedical abortion was consistently effective through 14 weeks and can be offered as an alternative to the surgical technique.