Risk factors for post-partum complications occurring after preeclampsia and HELLP syndrome: A study in 453 consecutive pregnancies

ObjectiveTo evaluate complications that occurred during the post-partum period for patients with preeclampsia or HELLP syndrome.Study designRetrospective analysis of 453 patients. The main outcome measures were maternal complications during post-partum period: fever >38.5 °C with proved infection, abdominal or perineal abscess, thrombo-embolic events, reoperation, need for blood transfusion, acute renal failure, eclampsia or disseminated intravascular coagulation. Statistic tests included univariate and multivariate analysis with stepwise descending logistic regression.ResultsPatients were divided into 305 preeclampsia (67.3%) and 20 HELLP syndrome (4.4%), 128 (28.3%) had both. Eighty-five patients (18.8%) had at least one post-partum complication. The most frequent complication was infection: fever (41 patients, 9.1%) and abscess (30 patients, 6.6%). Twenty-six transfusions (5.7%), 10 disseminated intravascular coagulation (2.2%), seven thromboembolic events (1.5%), seven reoperations (1.5%) and one eclampsia (0.2%) were observed. There was no acute renal failure, no pulmonary oedema and no maternal death. Stepwise logistic regression showed five independent risk factors associated with post-partum complications: ascites or pulmonary oedema (OR: 1.84, 95% CI: 1.01–3.37), platelet count <100 000/mm3 (OR: 1.96, 95% CI: 1.18–3.26), serum acid uric >360 μmol/l (OR: 2.36, 95% CI: 1.22–4.52), serum creatinine >120 μmol/l (OR: 2.99, 95% CI: 1.32–6.78), and proteinuria >5 g/l (OR: 1.80, 95% CI: 1.06–3.05).ConclusionWe conclude that severity criteria for preeclampsia or HELLP syndrome combined with caesarean section increased the risk of complication during the post-partum period.