کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3922627 1599904 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Secretory immunoglobulin A in saliva of women with oral and genital HPV infection
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Secretory immunoglobulin A in saliva of women with oral and genital HPV infection
چکیده انگلیسی

Secretory IgA contributes towards the protection of mucosal surfaces against invading microorganisms.ObjectivesQuantify secretory IgA titers in the saliva of women with HPV in the oropharynx and/or in the genital area.Subjects and methodsSeventy women with clinical genital HPV lesions and 70 women without HPV infection were tested for oral HPV DNA and the levels of total IgA in their saliva. One millilitre of saliva was collected, centrifuged and stored at −80 °C for the measurement of secretory IgA by nephelometry technique. A pool of oral pharyngeal cells was collected for HPV identification by polymerase chain reaction.ResultsOral HPV PCR was positive in 29 (21%) women (26 women with genital HPV and only 3 women without genital HPV). Titers of secretory IgA were extremely lower in-patients with HPV DNA in the oropharynx when compared to HPV negative women (p < 0.0001). Genital HPV and smoking were also associated to low levels of total sIgA in saliva (p < 0.01). After multivariable analyses only the presence of HPV in the oral cavity and/or in genital area, but not smoking, was related to low levels of total secretory IgA.ConclusionWomen with low levels of total secretory IgA could be more susceptible to having their oral mucosa colonized by HPV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 124, Issue 2, 1 February 2006, Pages 227–231
نویسندگان
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