کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3925638 1253132 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ADAM9 Expression is a Significant and Independent Prognostic Marker of PSA Relapse in Prostate Cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
ADAM9 Expression is a Significant and Independent Prognostic Marker of PSA Relapse in Prostate Cancer
چکیده انگلیسی

ObjectivesAdisintegrin and metalloprotease (ADAM) 9 has been implicated in tumour progression of prostate cancer. We evaluated the expression of ADAM9 on protein and messenger RNA (mRNA) level in a larger cohort of prostate cancer cases following prostatectomy and correlated the findings with clinicopathological parameters including prostate-specific antigen (PSA) relapse times.MethodsWe immunostained 198 clinicopathologically characterised prostate cancer cases for ADAM9. For 25 additional cases, ADAM9 mRNA of microdissected tumour and normal tissue was analysed via quantitative reverse transcriptase-polymerase chain reaction.ResultsADAM9 was significantly upregulated in prostate cancer compared with normal tissue on mRNA and protein level. ADAM9 protein expression was significantly associated with shortened PSA relapse-free survival in univariate and multivariate analyses, particularly in patients who had received prior androgen ablation.ConclusionsADAM9 is overexpressed in prostate cancer cases and is an independent prognostic marker of PSA relapse-free survival following radical prostatectomy. Further studies are needed to verify its role as a predictive marker of response to androgen ablation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology - Volume 54, Issue 5, November 2008, Pages 1097–1108
نویسندگان
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