کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3927929 1253191 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Quality of Life and Hormonal Disturbances in Testicular Cancer Survivors in Cisplatin Era
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The Quality of Life and Hormonal Disturbances in Testicular Cancer Survivors in Cisplatin Era
چکیده انگلیسی

ObjectivesTo assess the degree of hormonal abnormalities in testicular cancer survivors and the effect of these changes on patients’ quality of life.MethodsMen with complete remission of testicular cancer for over 2 yr were eligible. Patients completed the State-Trait Anxiety Inventory (STAI), the Hospital Anxiety and Depression Scale (HADS), Beck Depression Inventory (BDI), the International Index of Erectile Function (IIEF), and the Sexual Functioning Questionnaire (SFQ), and rated their physical and psychological well-being, quality of life, and relationship with their partner. Levels of the hormones testosterone, estradiol, thyreotropin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were determined. Relationships between hormone levels and questionnaire results were assessed.ResultsA total of 326 men were tested, of whom 269 were treated with platinum-based chemotherapy. The most common endocrine abnormalities were above-normal gonadotropin levels (LH, 55%, and FSH, 49% of cases) and lowered testosterone (15%). Twenty-seven percent (STAI) and 28% (HADS) of the patients had abnormal anxiety levels, while the depression rate was 15% (BDI) and 18% (HADS); 40% of patients had erectile dysfunction. Linear regression analysis excluding the influence of age showed higher depression levels in the BDI among patients with elevated LH (p = 0.010) or FSH (p = 0.017). Patients with above-normal LH showed increased sexual problems in the SFQ (p = 0.030). Elevated gonadotropins correlated with deteriorated physical well-being (p = 0.028). Men with abnormal estradiol were more prone to erectile dysfunction (p = 0.009).ConclusionsHormonal abnormalities have a negative impact on the quality of life of testicular cancer survivors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology - Volume 52, Issue 5, November 2007, Pages 1448–1455
نویسندگان
, , , , ,