کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3929581 1253232 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Challenges of Cancer Biomarker Profiling
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Challenges of Cancer Biomarker Profiling
چکیده انگلیسی

ObjectivesNew biomarkers are being developed to identify individuals at risk for cancer, detect disease earlier, determine prognosis, detect recurrence, predict response to particular agents, and monitor response to treatment. This article attempts to address some of the challenges facing the research and medical communities in the delivery of new biomarkers for individualized medicine.MethodsA variety of issues and barriers can affect the transfer of clinical tests from research to clinical practice. Differences in sample collection, handling or storage, and profiling techniques may influence the protein profile obtained by any method.ResultsStandard procedures and quality check schemes are necessary because there is a lack of definition to guarantee reproducibility of new procedures. From technical and economic viewpoints, the assay has to be sufficiently robust to be completed in community-based hospitals. Although traditionally cancer patients were treated with drugs of low toxicity or of high tolerance regardless of their efficacy in a given patient if the benefits of that drug are proven in both experimental and clinical conditions, recent advances have provided opportunities to adapt “tailored” treatment modalities. The evolving trend is the usage of patterns of markers instead of a single marker. Further challenges in biomarker development are in finding the relevant markers that have the right degree of specificity and sensitivity and a reliable test to measure the outcome.ConclusionsDiscovery, testing, and validation of clinically appropriate and commercially useful tumor markers should permit individualization of therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology - Volume 52, Issue 6, December 2007, Pages 1601–1609
نویسندگان
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