کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3929786 1253238 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systematic Evidence-Based Analysis of Plaque Injection Therapy for Peyronie's Disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Systematic Evidence-Based Analysis of Plaque Injection Therapy for Peyronie's Disease
چکیده انگلیسی

ObjectiveWe evaluated the peer-reviewed urology literature for intraplaque injection of medication for Peyronie's disease and assessed the quality of studies via rigorous evidence-based medicine criteria.MethodsWe performed a search of peer-reviewed literature looking at all agents used to treat Peyronie's disease by intraplaque injections. These were then evaluated using the Oxford Centre for Evidence-Based Medicine criteria, which ranks studies from strongest (level 1) to weakest (level 5) strength of evidence.ResultsOf the 19 studies found involving injection therapy for Peyronie's disease, 17 showed positive results. Six studies using injectable corticosteroids were identified and though all showed positive results, they were of level 4 quality. Two collagenase injection studies (one level 4 and one level 2 study) were identified, both of which showed positive results. All four verapamil injection studies found (three level 4 and one level 2 study) showed positive results. Seven papers involving interferon α2-β injections were evaluated (six level 4 and one level 1 study), five of which showed positive outcomes and two of which showed no significant benefit.ConclusionsNinety percent of the studies regarding Peyronie's disease showed positive outcomes. Unfortunately, most of these have not offered convincing evidence-based data, with only one positive study meeting level 1 Oxford criteria for clinical efficacy. Standardised outcome measures were not used, making comparisons difficult. These results reveal the need for the development of validated outcome measures and well-designed controlled trials to determine optimal therapeutic intervention for this disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology - Volume 51, Issue 3, March 2007, Pages 640–647
نویسندگان
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