کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3932185 | 1253322 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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چکیده انگلیسی
Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 95, Issue 8, 30 June 2011, Pages 2538-2541.e6
Journal: Fertility and Sterility - Volume 95, Issue 8, 30 June 2011, Pages 2538-2541.e6
نویسندگان
Kathryn G. Ph.D., Michelle R. B.Sc., Wendy B.S., Douglas R. M.D., Margrit Ph.D., Andrea M.D., Richard S. M.D., Angela B.S., Ricardo M.D., M.B.A., M.P.H., Richard S. Ph.D., Mark O. M.D., Ph.D., Jerome F. M.D., Ph.D.,