کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3932584 1253330 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sperm Cells for Artificial Reproduction and Germ Cell Transplantation
ترجمه فارسی عنوان
سلولهای اسپرم برای پرورش مصنوعی و پیوند سلول های ژرمین
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

Sperm retrieval for in vitro fertilization/intracytoplasmic sperm injection is the only medical procedure that enables a man with testicular azoospermia to father a child. In obstructive azoospermia after failed refertilization, microsurgical epididymal sperm aspiration is the gold standard, with retrieval rates up to 100%. In nonobstructive azoospermia (NOA), testicular spermatozoa (spermatids) can be recovered by testicular sperm extraction (TESE) in approximately half of the men. No parameters are available to definitively predict a successful recovery individually, but genetic factors, reduced testicular volume, and high serum follicle-stimulating hormone levels are associated with an unfavorable outcome. Retrieval surgery is well standardized, chiefly performed with microsurgical assistance and without severe local complications. Microsurgically assisted TESE (M-TESE) and TESE that is not microscopically supported in low-chance NOA patients may result in hypogonadism in the long term. In patients with Klinefelter syndrome, the outcome is worse with increasing age. For children before chemotherapy, M-TESE for stem cell preservation must be performed with minimal damage to the testicles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology Supplements - Volume 13, Issue 4, November 2014, Pages 83–88
نویسندگان
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