کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3933646 1253358 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trial
چکیده انگلیسی

ObjectiveTo test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer of embryos with a normal chromosomal pattern for the chromosomes studied with preimplantation genetic screening (PGS) compared with patients who had an embryo transfer without PGS.DesignProspective randomized controlled trial (RCT).SettingAcademic tertiary setting.Patient(s)Patients with AMA (≥35 years).Intervention(s)In an RCT, the clinical IR per embryo transferred was compared after embryo transfer on day 5 or 6 between the PGS group (analysis of chromosomes 13, 16, 18, 21, 22, X, and Y) and the Control group without PGS.Main Outcome Measure(s)No differences were observed between the PGS group and the Control group for the clinical IR (15.1%; 14.9%; rate ratio 1.01; exact confidence interval [CI], 0.25–5.27), the ongoing IR (at 12 weeks) (9.4%; 14.9%), and the live born rate per embryo transferred (9.4%; 14.9%; rate ratio 0.63; exact CI, 0.08–3.37). Fewer embryos were transferred in the PGS group (1.6 ± 0.6) than in the Control group (2.0 ± 0.6). A normal diploid status was observed in 30.3% of the embryos screened by PGS.Conclusion(s)In this RCT, the results did not confirm the hypothesis that PGS results in improved reproductive outcome in patients with AMA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 93, Issue 2, 15 January 2010, Pages 364–373
نویسندگان
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