کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3933671 | 1253358 | 2010 | 16 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Vaginal micronized progesterone versus intramuscular progesterone for luteal support in women undergoing in vitro fertilization–embryo transfer Vaginal micronized progesterone versus intramuscular progesterone for luteal support in women undergoing in vitro fertilization–embryo transfer](/preview/png/3933671.png)
ObjectiveTo study the outcome of IVF-ET in women who used vaginal P (vaginal P4) versus those who used P in oil via IM injection (IM-P4) for luteal support.DesignRetrospective cohort.SettingTertiary referral infertility center.Patient(s)A cohort of 544 women.Intervention(s)In 145 women, vaginal P4 was used, while in 399 women, IM-P4 was used for luteal support.Main Outcome Measure(s)The primary outcome was ongoing pregnancy rate. Secondary outcomes included other IVF-ET outcomes: rates of clinical pregnancy and pregnancy loss (chemical and miscarriage) and serum P levels during the luteal phase and early pregnancy.Result(s)Women who used vaginal P4 for luteal support had ongoing pregnancy rates (odds ratio [OR], 1.0675; 95% confidence interval [CI], 0.7587–1.5020) and rates of total pregnancy loss (OR, 1.0775; 95% CI, 0.7383–1.5727) that were not statistically different from those who used IM-P4. During the luteal phase, women who used vaginal P4 had mean serum P levels that were not statistically different from those who used IM-P4. However, during early pregnancy, mean P levels in pregnant women who used vaginal P4 were statistically significantly higher.Conclusion(s)In women undergoing IVF-ET according to the GnRH agonist long protocol, luteal support with vaginal P4 was associated with treatment outcomes that were no different from those associated with IM-P4 luteal support.
Journal: Fertility and Sterility - Volume 93, Issue 2, 15 January 2010, Pages 554–569