کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3933838 | 1253363 | 2009 | 6 صفحه PDF | دانلود رایگان |

ObjectiveA challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer.DesignRetrospective study.SettingMcGill Reproductive Center, Montreal, Canada.Patient(s)Women with endometrial thickness <6 mm on days 6–10 ultrasound (US) scan of IVM treatment.Intervention(s)In the human menopausal gonadotropin (hMG) group, 150 IU/day of hMG was started and in the estradiol group, 6 to 12 mg/day of micronized 17β-estradiol was initiated. Additional US scans were performed 2 to 3 days apart, until endometrial thickness reached ≥8 mm or a dominant follicle (>10 mm) was identified.Main Outcome Measure(s)Endometrial lining before oocyte retrival.Result(s)In both groups endometrial lining significantly thickened following treatment. However, hMG treatment resulted in a higher number of follicles ≥7 mm compared to estradiol (7.4 ± 4.8 vs. 3.4 ± 2.5, respectively) and a significantly higher percentage of mature oocytes that were identified on the day of oocyte retrieval (in vivo matured oocytes) (15.1% vs. 10.5%).Conclusion(s)In IVM designated cycles with a thin endometrium both low-dose hMG and micronized 17β-estradiol supplementation significantly improve endometrial thickness. However, low-dose hMG results in larger follicles and a greater number of in vivo matured oocytes.
Journal: Fertility and Sterility - Volume 92, Issue 3, September 2009, Pages 907–912