کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3934456 1253378 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Progesterone administration induces preimplantation embryonic loss in mice
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Progesterone administration induces preimplantation embryonic loss in mice
چکیده انگلیسی

ObjectiveTo evaluate the effect of progesterone during early pregnancy on pregnancy maintenance in mice.DesignExperimental study or laboratory investigation.SettingAn established molecular reproduction laboratory, Department of Biotechnology, S.V. University.Animal(s)Healthy virgin female Swiss albino mice of 8 weeks of age.Intervention(s)After confirmation of the heat period, adult female mice were mated with mature healthy males to achieve pregnancy. Inseminated females received intraperitoneal injections of progesterone at doses of 0, 1, 3.5, 7, 15, 25, or 50 mg/kg body weight on the first, third, and seventh day of pregnancy.Main Outcome Measure(s)Preimplantation embryonic loss.Result(s)Pregnancy failure was evidenced by reduction in the number of embryos in females injected with 7 (25.12 %), 15 (38.44 %), 25 (100%), and 50 (100%) mg progesterone/kg body weight. In females with a successful pregnancy, the numbers of corpora lutea and postimplantation loss per dam were comparable across all groups. No increase in the incidence of malformed fetuses was found in any progesterone-treated groups.Conclusion(s)Administration of supranormal levels of progesterone during early pregnancy caused a reduction in the number of implantations and an increase in preimplantation loss in mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 91, Issue 5, Supplement, May 2009, Pages 2137–2141
نویسندگان
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