Effect of implanted Cu/low-density polyethylene nanocomposite on the morphology of endometrium in the mouse

ObjectiveTo investigate the damage of endometrium caused by the implanted Cu/low-density polyethylene (LDPE) nanocomposite and the contraceptive effect of this novel copper-containing intrauterine device material.DesignExperimental animal study.SettingTongJi Medical College of Huazhong University of Science and Technology.Patient(s)Sixty healthy female mice.Intervention(s)Twenty mice received no implants, 20 mice received the Cu/LDPE nanocomposite, and 20 mice received bulk copper.Main Outcome Measure(s)Morphologic features of the endometrium, contraceptive effect, and surface condition of the implanted implants.Result(s)The contraceptive effect of both the Cu/LDPE nanocomposite and bulk copper is 100%, the damage of the endometrium caused by the Cu/LDPE nanocomposite is much less than that caused by bulk copper, and the surface of the implanted Cu/LDPE nanocomposite is much smoother and much softer than that of the implanted bulk copper.Conclusion(s)The contraceptive effect of the Cu/LDPE nanocomposite is comparable with that of bulk copper, and the damage of the endometrium caused by the Cu/LDPE nanocomposite is much less than that caused by bulk copper. The endometrium injury is related to the surface condition of the implanted intrauterine device material.