کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3935548 1253419 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Are varicoceles associated with increased deoxyribonucleic acid fragmentation?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Are varicoceles associated with increased deoxyribonucleic acid fragmentation?
چکیده انگلیسی

ObjectiveTo perform a literature search on the association between varicocele and sperm DNA fragmentation.DesignSystematic review.Patient(s)Men with a varicocele and infertility.Intervention(s)Varicocele repair.Main Outcome Measure(s)Does the presence of a varicocele increase seminal oxidative stress and sperm DNA fragmentation?Result(s)In men with a varicocele increased levels of reactive oxygen species and sperm DNA damage can be found. This is probably related to defective spermatogenesis in these patients. Seminal oxidative stress is believed to be the source of sperm DNA damage. Patients with a varicocele and oligospermia may also have a diminished seminal antioxidant capacity. After varicocele repair sperm DNA fragmentation decreases.Conclusion(s)Varicocele is associated with sperm DNA damage, and this sperm pathology may be secondary to varicocele-mediated oxidative stress. The beneficial effect of varicocelectomy on sperm DNA damage further supports the premise that varicocele may impair sperm DNA integrity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 96, Issue 6, December 2011, Pages 1283–1287
نویسندگان
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