کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3935638 1253421 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology
ترجمه فارسی عنوان
غلظت متابولیت فتالات ادرار در ارتباط با سابقه ناباروری و استفاده از تکنولوژی تولید مثل با کمک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

ObjectiveTo examine urinary phthalate metabolite concentrations in pregnant women with planned pregnancies in relation to history of infertility and use of assisted reproductive technology (ART).DesignPhthalate metabolite concentrations were measured in first-trimester urine samples collected from women participating in a prospective pregnancy cohort study.SettingPrenatal clinics.Patient(s)A total of 750 women, of whom 86 had a history of infertility. Forty-one women used ART to conceive.Intervention(s)None.Main Outcome Measure(s)Primary outcomes were concentrations of four metabolites of diethylhexyl phthalate (DEHP) and their molar sum (∑DEHP). Multivariable analyses compared phthalate metabolite levels in [1] women reporting a history of infertility vs. those who did not (comparison group); and [2] those who used ART to conceive the index pregnancy vs. women with a history of infertility who did not use ART.Result(s)Among women with a history of infertility, ∑DEHP was significantly lower in women who conceived after ART compared with those who did not (geometric mean ratio: 0.83; 95% confidence interval 0.71–0.98). Similar significant associations were observed for all of the individual DEHP metabolites. There were no differences in DEHP metabolite concentrations between women with a history of infertility and the comparison group.Conclusion(s)Women who used ART to conceive had lower first-trimester phthalate metabolite concentrations than women with a history of infertility who did not use ART. Further research is needed to explore whether those pursuing fertility treatments take precautions to avoid exposure to environmental toxins, to improve treatment outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 104, Issue 5, November 2015, Pages 1227–1235
نویسندگان
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