کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3935675 1253422 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome
چکیده انگلیسی

ObjectiveTo test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS).DesignProspective study in normal and PCOS women.SettingGeneral Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Massachusetts General Hospital.Patient(s)Six normal women and five women with PCOS.Intervention(s)Administration of diazoxide to lower circulating insulin concentrations.Main Outcome Measure(s)Characteristics of LH secretion as appraised by multiparameter deconvolution and estimation of approximate entropy.Result(s)Short-term administration of diazoxide had no effect on the secretion of LH in women with PCOS.Conclusion(s)Hyperinsulinemia resulting from insulin resistance in women with PCOS may not have a direct effect on gonadotropin secretion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 88, Issue 1, July 2007, Pages 118–124
نویسندگان
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