کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3936361 1253444 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: A randomized, double blind, placebo-controlled trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: A randomized, double blind, placebo-controlled trial
چکیده انگلیسی

ObjectiveTo evaluate the effectiveness of sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women.DesignPlacebo-controlled, double-blind, randomized trial.SettingUniversity hospital.Patient(s)Fifty-two women with an indication for diagnostic hysteroscopy.Intervention(s)Randomized women who had received either 200 μg of misoprostol (n = 25) or placebo (n = 27) sublingually 2 hours before hysteroscopy. Two subgroups (women with or without previous vaginal delivery) were formed.Main Outcome Measure(s)Number of women requiring cervical dilatation, duration of dilatation, ease of dilatation, and complications during procedure.Result(s)In the misoprostol group, 14 patients needed cervical dilatation, versus 21 in the placebo group. Duration of dilatation was longer in the placebo group than in the misoprostol group. In subgroup 1, seven patients in the misoprostol group (n = 13) and nine patients in the placebo group (n = 12) needed cervical dilatation. The duration of the dilatation was similar between the groups. In subgroup 2, both the need for cervical dilatation (58.3% vs. 80.0%) and the duration of dilatation (31.0 ± 18.8 vs. 73.0 ± 82.0 seconds) were found to be lower in the misoprostol (n = 15) than in the placebo (n = 12) group, respectively. Those differences were all not significant.Conclusion(s)Sublingual misoprostol before diagnostic hysteroscopy did not seem to facilitate cervical ripening statistically; however, the results are remarkable and are promising clinically. Further studies are required to reassess the use of sublingual misoprostol in patients before hysteroscopy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 93, Issue 7, 1 May 2010, Pages 2400–2404
نویسندگان
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